21454-19-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethanedione, 1,1'-(oxydi-4,1-phenylene)bis[2-phenylis used as an advanced intermediate for the manufacture of pharmaceuticals. Its unique characteristics contribute to the development of various drugs and medications.
Used in Biochemical Industry:
Ethanedione, 1,1'-(oxydi-4,1-phenylene)bis[2-phenylis used as an advanced intermediate in the production of biochemicals. Its chemical properties allow for its incorporation into a wide range of biochemical substances.
Used in Organic Chemistry:
Ethanedione, 1,1'-(oxydi-4,1-phenylene)bis[2-phenylis used as a chemical intermediate in various organic synthesis processes. Its presence in these reactions can lead to the creation of new organic compounds with potential applications in various industries.

Upstream product

• 59745-29-8 4,4'-di(phenylethynyl)diphenyl ether 
• 101-84-8 diphenylether 
• 103-80-0 phenylacetyl chloride 
• 51930-25-7 bis(p-phenylacetylphenyl) ether 

Downstream Products

• 106877-56-9 bis<4-di(4-phenyl-4-hydantoinyl)phenyl> ether 
• 123368-02-5 <4,4'-di(carboxyhydroxyphenylmethyl)phenyl>ether 
• 118163-44-3 bis<4-(2-phenyl-1,2-dihydroxyethyl)phenyl> ether 
• 3364-04-3 Bis-<4-(2.3.4.5.6-pentaphenyl)-phenyl>-aether 
• 86386-81-4 C₅₂H₃₆N₆O₃ 
• 13092-45-0 3,3'-(oxydi-1,4-phenylene)bis(2,4,5-triphenylcyclopenta-2,4-dien-1-one) 

Relevant academic research and scientific papers

An improved synthesis of bis(cyclopentadienone)

An improved strategy for the synthesis of 3,3′-(oxy-p-phenylene)bis(2,4,5-triphenylcyclopentadienone) was developed, which includes three steps: Friedel-Crafts reaction, oxidation and condensation. Importantly, the use of KMnO4 made the second step simple and efficient, which has potential application to synthesis of bis(cyclopentadienone)s. The course of oxidation has been confirmed by isolated intermediates.

A Novel Practical Reaction of Diarylalkynes With Sulfur Trioxide: Oxidation to 1,2-Diketones

A new reaction of arylalkynes with the SO3-dioxane complex gives the corresponding aromatic 1,2-diketones in good yield.

The 'inverse electron-demand' Diels-Alder reaction in polymer synthesis. Part 2. Some bis(1,2,4-triazines) as potential bis-diene monomers

Synthetic approaches to a series of 5,5'-linked bis(1,2,4-triazines) are described: these are potential monomers in Diels-Alder polymerisation processes.Oxidation of bis(α-bromophenylacetyl) substituted aromatic compounds with dimethyl sulfoxide, or (better) oxidation of diacetyl- or bis(phenylacetyl) substituted aromatic compounds with hydrogen bromide in dimethyl sulfoxide, gives the corresponding bis(1,2-diketones) and bis(α-keto aldehydes); these are converted into 3,3'-bis(methylsulfanyl)-5,5'-arylenebis(1,2,4-triazines) by reaction with S-methylthiosemicarbazide.The methylsulfanyl groups may then be oxidised by standard methods to give the corresponding methylsulfinyl or methylsulfonyl compounds, although the oxidised products show a tendency to decompose on storage.

New DMSO-Based Reagents in Oxidation of Double and Triple Bonds and Synthesis of 1,2-Diketones

Preparative possibilities of oxidation of arylethenes and arylethynes using new reagents, iodine or palladium compounds in dimethylsulfoxide, in syntheses of 1,2-diketones are considered.The system PdCl2-Me2SO is shown to possess lower activity as compared to I2-Me2SO in oxidation of the double bonds, higher selectivity in oxidation of the triple bonds of diarylethynes and phenylpropyne, but more sensitive to steric effects of the substrate.

Preparation of tetraketones

A method of preparing tetraketone precursors which are useful in the production of high temperature resistant polyquinoxaline resins. Suitable diketones are oxidized with a halogenating agent, such as cupric halide or hydrogen bromide, and dimethylsulfoxide to produce the corresponding tetraketone. The tetraketones which can be produced by the instant process have the formula: STR1 wherein R is hydrogen or an aryl, substituted aryl, heterocyclic or substituted heterocyclic radical and R' is an aryl, substituted aryl, arylalkyl, arylether, arylthioether, arylsulfoxide, arylsulfone, heterocyclic or substituted heterocyclic radical.