214540-82-6

Upstream product

• 1004-16-6 3-cyano-1-methylpyridinium iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 219786-72-8 1-Methyl-4-phenyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridine-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of tetrahydro- and dihydropyridines by hetero diels-alder reactions of enantiopure α,β-unsaturated sulfinimines

Intermolecular hetero Diels-Alder reactions of the enantiopure sulfinimine 11 with the enol ethers 12-16 at 20 °C and 11 kbar lead to the tetrahydropyridines 18-22 in high yield, with very good to good endo/exo selectivities, and with an induced diastereoselectivity of up to 2.1:1. The sulfinyl group in the adducts can be removed with MeLi followed by treatment with acetyl chloride or dimethyl sulfate. According to this procedure, 21 gives either N-acetyltetrahydropyridine 29 or the N-methyldihydropyridine 32. The intramolecular Diels-Alder reaction of 26 yields 27, which is transformed into 33 and 34, respectively.

Synthesis of 3-5-diacyl-4-phenyl-1,4-dihydropyridines

3,5-Diacyl-4-phenyl-1,4-dihydropyridines have been synthesized via a regio- and chemoselective addition of Ph2Cu(CN)Li2 to β-substituted N- alkylpyridinium salts, followed by acylation of the intermediate 1,4- dihydropyridines with t