214542-59-3Relevant academic research and scientific papers
PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DISEASE IN WHICH MITOCHONDRIAL BENZODIAZEPINE RECEPTOR PARTICIPATES
-
Page/Page column 42, (2010/11/23)
A compound represented by formula (I) (wherein ring A is a nitrogen-containing ring which may have a substituent(s), E is a binding bond or a spacer of which main chain has an atom number of 1-8, Q is a hydrogen atom, a hydrocarbon group which may have a
A mild one-pot synthesis of thieno[3,4-c]pyrazoles and their conversion into pyrazole analogs of o-quinodimethane
Baraldi, Pier Giovanni,El-Kashef, Hussein,Manfredini, Stefano,Pineda De Las Infantas, Maria J.,Romagnoli, Romeo,Spalluto, Giampiero
, p. 1331 - 1334 (2007/10/03)
The reaction of alkyl or aryl hydrazine hydrochlorides with 4-cyano-3-oxotetrahydrothiophene (1) in refluxing ethanol afforded, in a regioselective manner, the corresponding 2-alkyl- or 2-aryl-3-aminothieno[3,4-c]pyrazoles 3a-1 with good yields. As representative examples, the compounds 3a, 3e, and 3k, after standard acetylation procedure, have been efficiently converted into the corresponding sulfolenes 6a, 6e, and 6k which readily undergo sulfur dioxide extrusion upon heating and in the presence of dienophiles, such as N-phenylmaleimide and ethyl fumarate, give die corresponding [4+2] cycloadducts in good yields.
