214550-39-7Relevant academic research and scientific papers
Improved procedure for 3,4-dihydro-1H-2-benzopyran ring closure. A general access to 3-substituted isochromanes
Antonioletti, Roberto,Bovicelli, Paolo,Crescenzi, Benedetta,Lupattelli, Paolo
, p. 6751 - 6752 (2007/10/03)
A general method for the ring closure of 1-substituted 2-(- hydroxymethyl)-phenylethanols to 3-substituted isochromanes using p-TsOH supported on silica gel is reported.
Traceless linkers for solid-phase synthesis. Homo- and hetero-Diels-Alder reactions of o-quinodimethanes
Craig, Donald,Robson, Michael J.,Shaw, Simon J.
, p. 1381 - 1383 (2007/10/03)
The synthesis and Diels-Alder reactions of a polymer-supported o-quinodimethane are described. Reaction with dimethyl acetylenedicarboxylate, benzoquinone and trichloroacetonitrile as dienophiles gives respectively substituted naphthalenes or an isoquinoline off-resin, whilst reaction with aldehydes and imines gives polymer-supported benzodihydropyrans and tetrahydroisoquinolines. The latter heterocyclic products undergo Lewis or Br?nsted acid-mediated cleavage reactions which allow incorporation of further functionality at the point of cleavage whilst leaving no trace of attachment to the polymer support.
