214596-88-0Relevant articles and documents
Synthetic studies of 14-membered cyclopeptide alkaloids
East, Stephen P.,Joullie, Madeleine M.
, p. 7211 - 7214 (2007/10/03)
A strained 14-membered cyclopeptide was prepared from the Garner aldehyde derived from D-serine. The key steps in the synthesis were the construction of the alkyl-aryl ether linkage via an S(N)Ar reaction involving 4-fluorobenzonitrile and the macrolactamization using a modification of the Schmidt protocol involving an activated pentafluorophenyl ester.