214602-23-0

Upstream product

• 121873-01-6 6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 939-99-1 4-trifluoromethylbenzyl chloride 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 142354-87-8 diethyl 2-[(3,4-difluorophenylamino)methylene]malonate 
• 3863-11-4 3,4-difluoroaniline 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 214602-52-5 6-Fluoro-4-oxo-7-piperazin-1-yl-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 214602-58-1 6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 957138-28-2 1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,4-dihydro-7-morpholino-4-oxoquinoline-3-carboxylic acid ethyl ester 
• 1604045-10-4 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylicacid 
• 1604045-09-1 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(naphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-08-0 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-fluorophenyl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-07-9 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(furan-2-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-06-8 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(4-isopropylphenyl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-04-6 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(pyridin-4-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-03-5 7-(4-((1-cyclohexyl-1H-tetrazol-5-yl)(phenyl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-02-4 7-(4-((1-tert-butyl-1H-tetrazol-5-yl)(4-methoxynaphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-01-3 7-(4-((1-tert-butyl-1H-tetrazol-5-yl)(naphthalen-1-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604045-00-2 7-(4-((1-tert-butyl-1H-tetrazol-5-yl)(4-fluorophenyl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1604044-99-6 7-(4-((1-tert-butyl-1H-tetrazol-5-yl)(furan-2-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Investigation of Ugi-4CC derived 1H-tetrazol-5-yl-(aryl) methyl piperazinyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid: Synthesis, Biology and 3D-QSAR analysis

Novel series of 7-piperazinylquinolones with tetrazole derivatives were synthesized and evaluated for their antibacterial activity against various strains of Staphylococcus aureus. All the synthesized compounds showed significant in vitro antibacterial ac

ANTIVIRAL AGENTS

Compounds are provided having utility for the treatment of viral infections, particularly HCV.

Synthesis and antibacterial activity of 1-(substituted-benzyl)-6- fluoro,1,4-dihydro-4-oxoquinoline-3-carboxylic acids and their 6,8-difluoro analogs

Alkylation of 6,7-difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester with substituted-benzyl chlorides gave 1-(substituted-benzyl)-6,7- difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl esters. Their treatment with piperazine or N-methylpiperazine in pyridine yielded 1- (substituted-benzyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline- 3-carboxylic acid ethyl esters which were hydrolyzed with aqueous sodium hydroxide and then acidified with hydrochloric acid afforded the desired 1- (substituted-benzyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline- 3-carboxylic acids. The 6,8-difluoro analogs were prepared similarly using 6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylic acids. The 6,8-difluoro analogs were prepared similarly using 6,7,8-trifluoro-4-hydroxyquinoline-3- carboxylic acid ethyl ester as a starting material. Some of these quinolones demonstrated fairly good antibacterial activities. Among them, 6-fluoro-1- (4-fluorophenylmethyl)-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3- carboxylic acid (7d) and 6,8-difluoro-1-(3-fluorophenylmethyl)-1,4-dihydro- 7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (8c) are two of the best.