214604-70-3

Upstream product

• 3392-07-2 tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate 
• 214604-67-8 (2S,3S)-4-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-hydroxy-butyric acid 
• 100-51-6 benzyl alcohol 
• 214604-69-0 (2S,3S)-4-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-2-{2-[(2S,3S)-4-(6-amino-purin-9-yl)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-hydroxy-butyrylamino]-acetylamino}-3-hydroxy-butyric acid benzyl ester 
• 214604-65-6 N-Boc-γ-guanyl-L-allo-threonylglycine 
• 214604-64-5 N-Boc-γ-adenyl-L-allo-threonylglycine 
• 214604-66-7 (2S,3S)-4-(6-Amino-purin-9-yl)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-hydroxy-butyric acid 
• 214604-62-3 (2S,3S)-2-Amino-4-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3-hydroxy-butyric acid benzyl ester 
• 214604-60-1 (2S,3S)-2-Amino-4-(6-amino-purin-9-yl)-3-hydroxy-butyric acid benzyl ester 

Relevant academic research and scientific papers

Application of L-threonine aldolase-catalyzed reaction for the preparation of a peptidic mimetic of RNA: A leading compound of vero-toxin inhibitors

A peptidic mimetic of RNA having a guanine-adenine-guanine code as a base sequence was prepared as a leading compound of Vero-toxin inhibitors. The synthesized hexapeptide is composed from two γ-guanyl-β-hydroxy-α-L- amino acids and one γ-adenyl-β-hydroxy-α-L-amino acid, which were prepared by using L-threonine aldolase-catalyzed reaction, in addition to three glycines. On designing this peptide, the β-hydroxyl groups in the novel α- amino acids are compared to the 2'-hydroxyl groups of RNA, and glycine was chosen as the mimic of the phosphate groups in the RNA backbone.