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Usage

Uses

Used in Organic Synthesis:
C₁₂H₁₀F₂N₂O is used as an organic synthesis intermediate for [application reason] in the field of chemical production process. Its unique molecular structure allows for the creation of a variety of complex organic compounds, making it a valuable component in the synthesis of various molecules.
Used in Pharmaceutical Industry:
C₁₂H₁₀F₂N₂O is used as a pharmaceutical intermediate for [application reason] in the development of new drugs and medications. Its specific functional groups and structural features make it a promising candidate for the design and synthesis of novel pharmaceutical compounds.
Used in Laboratory Research and Development:
C₁₂H₁₀F₂N₂O is used as a research compound for [application reason] in the field of scientific research. It serves as a valuable tool for chemists and researchers to study its properties, reactivity, and potential applications in various chemical and biological processes.

Synthesis

The DMF solution of 62 is heated to 80° C. to complete the Claisen rearrangement. Upon completion, the reaction is cooled to 0° C. A solution of benzene 1,2-diamine 18 (0.90 equiv) in DMF (7.5 mL) is sparged with nitrogen and then charged to the reaction maintaining a temperature below 25° C.; rinsing with DMF (2.5 mL) to complete the transfer. The temperature is adjusted to 20° C. and mixed until reaction completion. The temperature is adjusted to 40° C. and a 10 wt % aqueous ammonium chloride solution (95 mL) is slowly charged to crystallize the product 64. The slurry is cooled and filtered, washing the wet cake aqueous DMF and then water. The wet cake is dried to remove residual water. The crude product 64 can be recrystallized from toluene or toluene/heptane. The typical yield of 64 is 65%.