214709-69-0Relevant academic research and scientific papers
Directed Evolution of Artificial Metalloenzymes in Whole Cells
Bloomer, Brandon J.,Chen, Reichi,Clark, Douglas S.,Gu, Yang,Hartwig, John F.,Liu, Zhennan
supporting information, (2021/12/24)
Artificial metalloenzymes (ArMs), created by introducing synthetic cofactors into protein scaffolds, are an emerging class of catalyst for non-natural reactions. Although many classes of ArMs are known, in vitro reconstitution of cofactors and proteins ha
Asymmetric N-H Insertion of secondary and primary anilines under the catalysis of palladium and chiral guanidine derivatives
Zhu, Yin,Liu, Xiaohua,Dong, Shunxi,Zhou, Yuhang,Li, Wei,Lin, Lili,Feng, Xiaoming
, p. 1636 - 1640 (2014/03/21)
Efficient enantioselective N-H insertion reactions of secondary and primary anilines were catalyzed by palladium(0) in combination with chiral guanidine derivatives. A broad range of substituted anilines were tolerated, and the corresponding products were obtained in high yield (up to 99 %) with good enantioselectivity (up to 94 % ee) under mild reaction conditions. The N-H insertion mechanism was examined by the study of kinetic isotope effects, control experiments, HRMS, and spectroscopic analysis. Hidden talents: Chiral guanidine derivatives were developed as useful ligands for the enantioselective insertion of carbenoids into the N-H bonds of secondary and primary anilines in combination with palladium(0), which was not previously known to promote asymmetric N-H insertion (see scheme; dba=dibenzylideneacetone). The N-H insertion mechanism was examined by kinetic isotope studies, control experiments, HRMS, and spectroscopic analysis. Copyright
