214759-74-7

Basic information

• Product Name: 4-MORPHOLINOBENZYLAMINE
• Synonyms: BUTTPARK 98\50-31;CHEMBRDG-BB 4012455;CBI-BB ZERO/006142;AKOS B033642;4-(4-MORPHOLINYL)BENZYLAMINE;4-MORPHOLIN-4-YL-BENZYLAMINE;4-MORPHOLINOBENZYLAMINE;1-(4-Morpholin-4-ylphenyl)methanamine
• CAS NO: 214759-74-7
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Product Categories: Amines and Anilines;Heterocycles;Aminomethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 214759-74-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 44℃
• Boiling Point: 361.4°Cat760mmHg
• Flash Point: 172.3°C
• Appearance: /
• Density: 1.113g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.51±0.10(Predicted)
• CAS DataBase Reference: 4-MORPHOLINOBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MORPHOLINOBENZYLAMINE(214759-74-7)
• EPA Substance Registry System: 4-MORPHOLINOBENZYLAMINE(214759-74-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• HazardClass: IRRITANT
• Hazardous Substances Data: 214759-74-7(Hazardous Substances Data)

Usage

General Description

4-Morpholinobenzylamine is a chemical compound that belongs to the class of aromatic amines. It is an organic compound with the molecular formula C12H16N2O, and it contains a morpholine ring attached to a benzene ring with an amine group. 4-MORPHOLINOBENZYLAMINE is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as an intermediate in the production of dyes, rubber chemicals, and surfactants. Additionally, 4-morpholinobenzylamine has been studied for its potential therapeutic applications, particularly in the treatment of neurological disorders and as a potential anti-cancer agent. Overall, this compound has diverse applications and is an important intermediate for the synthesis of various organic compounds.

InChI:InChI=1/C11H16N2O/c12-9-10-1-3-11(4-2-10)13-5-7-14-8-6-13/h1-4H,5-9,12H2

Upstream product

• 183557-77-9 (4-morpholin-4-yl-phenyl)-amide 
• 1001242-92-7 2-(4-morpholin-4-ylbenzyl)-1H-isoindole-1,3(2H)-dione 
• 10282-31-2 4-morpholinobenzonitrile 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 1001242-93-8 methyl 1-[(dimethylamino)sulfonyl]-2-[(4-morpholin-4-ylbenzyl)amino]-5-nitro-1H-benzimidazole-6-carboxylate 
• 1018826-34-0 t-butyl 4-morpholinobenzylcarbamate 
• 1601403-31-9 N-(4-morpholinobenzyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide 
• 1429297-45-9 C₂₆H₂₆Cl₂FN₃O₄ 
• 1416335-35-7 N-[5-(2-amino-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-6-yl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide 
• 1416337-25-1 6-bromo-1-{[4-(4-morpholinyl)phenyl]methyl}-1H-benzimidazol-2-amine 
• 1416337-24-0 (2-amino-5-bromophenyl){[4-(4-morpholinyl)phenyl]methyl}amine 
• 1416337-23-9 (5-bromo-2-nitrophenyl){[4-(4-morpholinyl)phenyl]methyl}amine 
• 1255097-90-5 C₁₇H₁₈BrN₅O 
• 1121052-08-1 3-chloro-6-furan-2-yl-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid 4-morpholin-4-yl-benzylamide 
• 389602-07-7 N-(4-Morpholin-4-yl-phenylmethyl)-3-(biphenyl-2-carbonyl-amino)-benzoic acid amide 

Relevant articles and documents

Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents

A series of benzamide scaffolds were designed and synthesized by the thiazinone ring opening of PBTZ169, and N-benzyl 3,5-dinitrobenzamides were finally identified as anti-TB agents in this work. 3,5-Dinitrobenzamides D5, 6, 7, and 12 exhibit excellent in vitro activity against the drug susceptive Mycobacterium tuberculosis H37Rv strain (MIC: 0.0625 μg/mL) and two clinically isolated multidrug-resistant strains (MIC 0.016-0.125 μg/mL). Compound D6 displays acceptable safety and better pharmacokinetic profiles than PBTZ169, suggesting its promising potential to be a lead compound for future antitubercular drug discovery.

Anti-Inflammation Compounds

The present invention refers to: a compound having the general formula (I), wherein n is 0, 1, 2 or; m is 0, 1, 2 or 3; o is 0, 1, 2 or 3; W, X, Y and Z are independently selected from CH, N or N-oxide; A is NR4, C═O, C═S, OP(O)(O), P═O, CH2, or a heteroarly selected from the group consisting of (a), (b), (c), (d), (e), (f), (g); V is C═O, O, S, CH2, or NR5; as well as its use in treating inflammatory diseases such as asthma, COPD, inflammation post infection, arthritis, atherosclerosis, pain and dermatitis.

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.