21478-95-5 Usage
Description
N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is a chemical compound characterized by the presence of a thiazole ring, to which a bromine and a methyl group are attached. Additionally, it features an acetamide group linked to the thiazole ring. N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is recognized for its potential as a building block in the synthesis of pharmaceuticals and agrochemicals due to its unique structural features and demonstrated biological activities.
Uses
Used in Pharmaceutical Industry:
N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its antifungal and antimicrobial properties make it a valuable component in the development of new drugs targeting a range of infections and diseases.
Used in Agrochemical Industry:
In the agrochemical sector, N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide serves as a crucial building block for the creation of novel agrochemicals. Its antifungal and antimicrobial properties are harnessed to develop products that protect crops from various pathogens, thereby enhancing agricultural productivity.
Used in Drug Development:
N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is employed as a starting material in drug development, particularly for compounds with potential anti-inflammatory or antioxidant properties. The presence of the thiazole ring suggests that this compound may contribute to the discovery of new therapeutic agents with diverse biological activities.
Overall, N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is a versatile and promising compound with applications spanning across the pharmaceutical, agrochemical, and broader chemical and biological research fields. Its unique structure and biological properties position it as a valuable asset in the development of innovative products and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 21478-95-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,7 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 21478-95:
(7*2)+(6*1)+(5*4)+(4*7)+(3*8)+(2*9)+(1*5)=115
115 % 10 = 5
So 21478-95-5 is a valid CAS Registry Number.
21478-95-5Relevant articles and documents
Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents
Al-Rashood, Sarah T.A.,Hassan, Ghada S.,El-Messery, Shahenda M.,El-Taher, Kamal E.H.,Hefnawy, Mohamed M.,Al-Omar, Mahmmed A.,El-Subbagh, Hussein I.
, p. 445 - 453 (2016)
New derivatives of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124, 3), were synthesized as continuation to our previous patented efforts. Compounds 15 and 20 showed marginal hypnotic potency compared to 3. Compounds 15 (0.78 mmol/kg) and 20 (0.39 mmol/kg) showed remarkable 100% protection against PTZ induced convulsions with two and four fold increase in activity than sodium valproate (1.38 mmol/kg), respectively. Molecular modeling studies showed hydrogen bonding interaction between 15 and Thr56 residues at the binding site of GABAA. Superposition, flexible alignment and surface mapping of 15, 20 and diazepam supports their biological resemblance where ADMET study suggested that those compounds could be used as oral anticonvulsants.
5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS
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Page/Page column 41, (2010/02/07)
Compounds of Formula I in free or salt form, wherein R1,R2,R3,R4, and R5, have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.