21482-31-5Relevant academic research and scientific papers
Synthesis of [benzyl-7-3H] and [benzoyl-7-14C] methyl 4-(2,5-dihydroxybenzylamino)benzoate
Taylor, George F.,Hristova-Kazmierski, Maria K.,Ley, F. Robert,Kepler, John A.
, p. 187 - 192 (1996)
4-Amino[7-14C]benzoic acid (3) is prepared by carbonation of the lithium salt of N,N-bis(trimethylsilyl)aniline. The methyl ester (4) of 3 is generated with trimethylsilyldiazomethane, and 4 is coupled with 2,5-dihydroxybenzaldehyde to yield methyl 4-(2,5-dihydroxybenzylimino)[7-14C]benzoate (5). 5 is reduced with sodium cyanoborohydride to give methyl 4-(2,5-dihydroxybenzylamino)[7-14C]-benzoate with a specific activity of 38.9 mCi/mmol. Unlabeled 5 is reduced with tritium gas to give methyl 4-(2,5-dihydroxy[7-3H]-benzylamino)benzoate with specific activity of 7.6 Ci/mmol.
[14C] and [13C] labellings from N-(2-diethylaminoethyl)-4-iodobenzamide, and N-(3-deimethylaminopropyl)-4-iodobenzamide, melanoma tracers
Moreau,Parry,Bayle,Papon,Labarre,Veyre
, p. 805 - 813 (2007/10/02)
N-(2-diethylaminoethyl)-4-iodobenzamide (I) and N-(3-dimethylaminopropyl)-4-iodobenzamide (II), recently developed in our laboratory, are promising agents for metastatic melanoma detection in nuclear medicine. In order to study their 'in vivo' metabolism,
