214848-35-8

Upstream product

• 142166-00-5 methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 
• 185629-31-6 methyl 3-fluoro-4-nitrobenzoate 
• 201294-48-6 methyl 4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 

Relevant academic research and scientific papers

SMALL MOLECULE STING ANTAGONISTS

The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis (NASH), pulmonary fibrosis, lupus, sepsis, rheumatoid arthritis (RA), type I diabetes, STING- associated vasculopathy with onset in infancy (SAVI), Aicardi-Goutieres syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), retinal vasculopathy, neuroinflammation, systemic inflammatory response syndrome, pancreatitis, cardiovascular disease, renal fibrosis, stroke and age-related macular degeneration (AMD).

Phenyl-substituted-2enamino-keto nitriles

The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): 1in whichAr, X, Z, Y and K are each as defined in the description, to a plurality of processes for their preparation and to their use as herbicides and pesticides.