21489-74-7 Usage
Derivative of
Tetralin
Functional Groups
Substituted amine (2-amino)
Two hydroxyl groups (5,6-dihydroxy)
Pharmaceutical/Medicinal Properties
Potential neuroprotective effects
Antioxidant properties
Potential Therapeutic Use
Treatment of neurodegenerative diseases, such as Parkinson's disease
Interest in Medicinal Chemistry
Subject of interest for medicinal chemistry and drug development
Synthesis Method
Synthesized through specific chemical reactions
Applications
Potential applications in various research and pharmaceutical fields
Check Digit Verification of cas no
The CAS Registry Mumber 21489-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,8 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 21489-74:
(7*2)+(6*1)+(5*4)+(4*8)+(3*9)+(2*7)+(1*4)=117
117 % 10 = 7
So 21489-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO2.BrH/c11-7-2-3-8-6(5-7)1-4-9(12)10(8)13;/h1,4,7,12-13H,2-3,5,11H2;1H
21489-74-7Relevant academic research and scientific papers
Synthesis and pharmacology of some 2 aminotetralins. Dopamine receptor agonists
McDermed,McKenzie,Phillips
, p. 362 - 367 (2007/10/05)
A series of 2 amino 1,2,3,4 tetrahydronaphthalene compounds bearing substituents on the nitrogen and in the aromatic ring was synthesized from β tetralone intermediates. Compounds were screened in vivo for dopaminergic activity using tests in which apomorphine was especially active. It was found that apparent dopaminergic activity is inherent in 2 dialkylaminotetralins, the dipropylamine substitution being the most consistently productive amine group studied. Activity was greatly enhanced by proper substitution in the aromatic ring. The 5,6 dihydroxy group was the best potentiating group found. These data support the idea that the extended conformation for the phenylethylamine moiety of apomorphine and dopamine is favorable for dopaminergic agonist activity. They also suggest that an unetherified catechol group may not be essential for such activity.
