214892-52-1Relevant articles and documents
The formal total synthesis of epothilone A
Kalesse, Markus,Quitschalle, Monika,Claus, Eckhard,Gerlach, Kai,Pahl, Axel,Meyer, Hartmut H.
, p. 2817 - 2823 (2007/10/03)
The formal total synthesis of epothilone A is described. The key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reaction (RCM) and the diastereoselective alkylation at C8. Aldehyde 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An efficient route to keto acid 5 is described.
Synthesis of the northern hemisphere of epothilone A by a ten-membered ring closing metathesis reaction
Gerlach, Kai,Quitschalle, Monika,Kalesse, Markus
, p. 3553 - 3556 (2007/10/03)
The synthesis of the strained epothilone analog containing a ten- membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed
