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5-Aminouridine, hydrochloride salt, is a nucleoside analog and antiviral agent derived from uridine. It is a chemical compound that is soluble in water and is widely used in research and laboratory settings to investigate viral replication and RNA metabolism. Its antiviral properties have been demonstrated against a range of RNA viruses, positioning it as a promising candidate for drug development and antiviral therapies.

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  • 2149-76-0 Structure
  • Basic information

    1. Product Name: 5-AMINOURIDINE, HYDROCHLORIDE SALT
    2. Synonyms: 5-aminouridine;5-AminouridineHClsalt;5-amino-1-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone;5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;5-azanyl-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;5-Aminouridine Hcl
    3. CAS NO:2149-76-0
    4. Molecular Formula: C9H13N3O6
    5. Molecular Weight: 259.21602
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2149-76-0.mol
  • Chemical Properties

    1. Melting Point: 214-216 °C
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.712g/cm3
    6. Refractive Index: 1.666
    7. Storage Temp.: −20°C
    8. Solubility: N/A
    9. PKA: 9.31±0.10(Predicted)
    10. CAS DataBase Reference: 5-AMINOURIDINE, HYDROCHLORIDE SALT(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-AMINOURIDINE, HYDROCHLORIDE SALT(2149-76-0)
    12. EPA Substance Registry System: 5-AMINOURIDINE, HYDROCHLORIDE SALT(2149-76-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2149-76-0(Hazardous Substances Data)

2149-76-0 Usage

Uses

Used in Pharmaceutical Research:
5-Aminouridine, hydrochloride salt is used as a research tool for studying the molecular mechanisms of viral infections and the development of potential antiviral treatments. Its ability to inhibit viral replication aids in understanding the processes involved in viral life cycles and the identification of new therapeutic targets.
Used in Antiviral Drug Development:
In the pharmaceutical industry, 5-Aminouridine, hydrochloride salt is used as a lead compound in the development of new antiviral drugs. Its activity against various RNA viruses makes it a valuable asset in the search for effective treatments against viral diseases.
Used in Virology Laboratories:
5-Aminouridine, hydrochloride salt is used as an experimental reagent in virology laboratories to study the replication of RNA viruses. It helps researchers to gain insights into the mechanisms of viral replication and to test the efficacy of potential antiviral agents.
Used in Molecular Biology:
In molecular biology, 5-Aminouridine, hydrochloride salt is used as a nucleoside analog to investigate RNA metabolism and the function of RNA in various biological processes. Its incorporation into RNA molecules allows researchers to study the stability, structure, and function of RNA in cells.
Used in Diagnostics:
5-Aminouridine, hydrochloride salt may also be used in the development of diagnostic tools for viral infections. Its ability to interact with viral RNA could be harnessed to create assays that detect the presence of specific viruses or monitor the progression of viral diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 2149-76-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,4 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2149-76:
(6*2)+(5*1)+(4*4)+(3*9)+(2*7)+(1*6)=80
80 % 10 = 0
So 2149-76-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H13N3O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2,10H2,(H,11,16,17)

2149-76-0Upstream product

2149-76-0Downstream Products

2149-76-0Relevant articles and documents

H-phosphonate synthesis of oligoribonucleotides containing modified bases. I. Photoactivatable derivatives of oligoribonucleotides with perfluoroarylazide groups in heterocyclic bases

Repkova,Ivanova,Komarova,Meshchaninova,Kuznetsova,Venyaminova

, p. 612 - 622 (2007/10/03)

H-phosphonate synthesis was proposed for oligoribonucleotides containing a bromine atom or an ethylenediamine linker at positions C5 or C8 of uridine or adenosine, respectively. Novel photoactivatable derivatives of oligoribonucleotides harboring a p-azidotetrafluorobenzoyl group attached to uridine or adenosine through the diamino linker were synthesized.

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