214901-17-4Relevant articles and documents
Preparation of new half sandwich ruthenium arene complexes with aminophosphines as potential chemotherapeutics
Aliende, Cristina,Pérez-Manrique, Mercedes,Jalón, Félix A.,Manzano, Blanca R.,Rodríguez, Ana M.,Cuevas, José Vicente,Espino, Gustavo,Martínez, Ma ángeles,Massaguer, Anna,González-Bártulos, Marta,De Llorens, Rafael,Moreno, Virtudes
, p. 171 - 188 (2012)
Aminophosphines 2-(diphenylphosphino)-1-methylimidazole (dpim) and diphenyl-2-pyridylphosphine (PPh2py) have been used to prepare two series of Ru(II) arene complexes of formulae [(η6-p-cymene) Ru(κ2-O,O′-X)(κ1-P-dpim)]Y (series a: 1a·Y-3a·Y) and [(η6-p-cymene) Ru(κ2-O,O′-X)(κ1-P-PPh2py)]Y (series b: 1b·Y-3b·Y) (where X = acac, acetylacetonate; bzac, benzoyl acetonate; dbzm, dibenzoyl methanoate; Y = BF4, BPh 4). The structures of 1a·BF4, 1a·BPh 4, 3a·BF4, 1b·BPh4 and 3b·BPh4 were determined by X-ray diffraction. The tetrafluoroborate derivatives are more soluble in organic solvents than their tetraphenylborate counterparts. Five BF4- derivatives (all except the unstable 1b·BF4) were selected to evaluate the cytotoxic behavior in vitro against the human cancer cell lines MCF-7 (breast cancer) and CAPAN-1 (pancreatic cancer). 2b·BF4 and 3b·BF4 exhibited IC50 values similar to those of cisplatin. Electrophoresis and AFM studies showed good correspondence between the biological activity levels of 2b·BF4 and 3b·BF 4 and their ability to modify the DNA structure. Hydrolytic studies indicate that aquation could be involved in the activation mechanism of these complexes and confirm that the hydrolysis rate of 3b·BF4 is higher than that of 3a·BF4. Thus, the cytotoxic activity trends are explained in terms of the higher reactivity of derivatives from series b, which in turn is rationalized as being the result of the electronic features of dpim and PPh2py established by cyclic voltammetry measurements.
Ruthenium arene derivatives with PN hemilabile ligands. P-C cleavage and phosphine to phosphinite transformation
Caballero, Agustin,Jalon, Felix A.,Manzano, Blanca R.,Espino, Gustavo,Perez-Manrique, Mercedes,Mucientes, Antonio,Poblete, Francisco J.,Maestro, Miguel
, p. 5694 - 5706 (2008/10/09)
The synthesis of ruthenium arene derivatives with hemilabile ligands was investigated. An unexpected reactivity of the ligand was observed during the course of the synthesis which was transformed by the reaction with methanol into diarylphosphinite. The transformation of [RuCl2(arene)(κ] 1-PN)] type neutral derivatives in to the cationic species [RuCl(arene)κ2-PN)]X was achieved. The protonation of the neutral derivatives with HBF4 resulted in the formation of [RuCl 2(arene)(κ1-PNH)]BF4 which exhibited a hydrogen bond.
Ruthenium(II) complexes containing both arene and functionalized phosphines. Synthesis and catalytic activity for the hydrogenation of styrene and phenylacetylene
Moldes, Isabel,De La Encarnacion, Esther,Ros, Josep,Alvarez-Larena, Angel,Piniella, Joan F.
, p. 165 - 174 (2007/10/03)
The [RuCl2(η6-arene)]2 complex reacts with PPh2R (R=H, Py, CH2Py, CCPh, CCtBu and CCp-Tol) ligands in CH2Cl2 to give neutral P-coordinated ruthenium(II) complexes [RuC
