214962-93-3

Upstream product

• 214962-83-1 3-Benzyloxy-2,2-dichloro-propionic acid 2-[(1R,2S,4S)-7,7-dimethyl-1-(2-oxo-oxazole-3-carbonyl)-bicyclo[2.2.1]hept-2-yloxy]-ethyl ester 
• 214962-91-1 (4R,5R)-5-((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-4-methoxy-oxazolidin-2-one 
• 214963-02-7 (4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-4-methoxy-oxazolidin-2-one 

Downstream Products

• 214962-94-4 ((1R,2R,3R)-4-Benzyloxy-2-hydroxy-1,3-dimethyl-butyl)-carbamic acid tert-butyl ester 
• 214962-96-6 Acetic acid (1S,2R)-3-benzyloxy-1-((R)-1-tert-butoxycarbonylamino-ethyl)-2-methyl-propyl ester 

Relevant academic research and scientific papers

The highly enantiocontrolled functionalization of a 2-oxazolone heterocycle by intramolecular radical-based addition. A chiral synthon for 2- amino alcohols which contain three contiguous stereocenters

The intramolecular Ru(II)-catalyzed radical addition of the 2,2- dichloroacyl pendant group to the 2-oxazolone moiety followed by reductive dechlorination with (TMS)3SiH provides an effective tool for the formation of the chiral 2-amino alcohol synthon in a completely regio- and stereocontrolled manner. The prepared synthon is useful in the preparation of isomers of unusual amino hydroxy acids including the key component of bleomycins.