2150-36-9

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3,5-DIACETOXYBENZOATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs and therapeutic agents.
Used in Materials Chemistry:
In the field of materials chemistry, METHYL 3,5-DIACETOXYBENZOATE is utilized as a precursor for the synthesis of advanced materials with specific properties. Its versatility allows for the creation of materials with tailored characteristics for various applications, such as polymers, coatings, and adhesives.
Used in Organic Chemistry Research:
METHYL 3,5-DIACETOXYBENZOATE serves as a key compound in organic chemistry research, where it is employed to study reaction mechanisms, explore new synthetic routes, and develop innovative methodologies. Its unique reactivity and properties make it an essential tool for advancing the understanding of organic chemical processes.

InChI:InChI=1S/C12H12O6/c1-7(13)17-10-4-9(12(15)16-3)5-11(6-10)18-8(2)14/h4-6H,1-3H3

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 108-24-7 acetic anhydride 

Downstream Products

• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 114223-14-2 methyl 3-acetoxy-5-hydroxybenzoate 

Relevant academic research and scientific papers

Polyhydroxybenzoic acid derivatives as potential new antimalarial agents

With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria since 2015 (from 211 million in 2015 to 229 million in 2019). This trend could partially be due to the development of resistance to all the current drugs. Therefore, there is an urgent need for new alternatives. We have, thus, selected common natural scaffolds, polyhydroxybenzoic acids, and synthesized a library of derivatives to better understand the structure–activity relationships explaining their antiplasmodial effect. Only gallic acid derivatives showed a noticeable potential for further developments. Indeed, they showed a selective inhibitory effect on Plasmodium (IC50 ~20 μM, SI > 5) often associated with interesting water solubility. Moreover, this has confirmed the critical importance of free phenolic functions (pyrogallol moiety) for the antimalarial effect. Methyl 4-benzoxy-3,5-dihydroxybenzoate (39) has, for the first time, been recognized as a potential lead for future research because of its marked inhibitory activity against Plasmodium falciparum and its significant hydrosolubility (3.72 mM).

Samarium trifluoromethanesulfonate: An efficient moisture tolerant acylation catalyst under solvent-free condition

Samarium trifluoromethanesulfonate catalyzed the acylation of phenols, alcohols, thiols, free reducing sugars, and glycosides in excellent yields at ambient temperature under solvent-free condition using stoichiometric amounts of various anhydrides. (Chemical Equation Presented). Copyright Taylor & Francis Group, LLC.

Novel chemoselective de-esterification of esters of polyacetoxy aromatic acids by lipases

Candida cylindracea lipase (CCL) and porcine pancreatic lipase (PPL) have been used for deacetylation of peracetates of methyl and ethyl esters of six different polyphenolic acids in organic solvents. Exclusive de-esterification of the ester groups derived from the phenolic hydroxy and aliphatic acid over the ester group of the aromatic acid and aliphatic alcohol has been achieved affording the corresponding esters of phenolic acids in as high yields as 90-97%. The results have been corroborated with the mechanism of lipase action.