215050-05-8

Basic information

• Product Name: (S)-2-Amino-3-[4-(2-azido-ethoxy)-3-nitro-benzoylamino]-propionic acid benzyl ester
• Synonyms: (S)-2-Amino-3-[4-(2-azido-ethoxy)-3-nitro-benzoylamino]-propionic acid benzyl ester
• CAS NO: 215050-05-8
• Molecular Weight: 428.404
• Mol File: 215050-05-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-Amino-3-[4-(2-azido-ethoxy)-3-nitro-benzoylamino]-propionic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Amino-3-[4-(2-azido-ethoxy)-3-nitro-benzoylamino]-propionic acid benzyl ester(215050-05-8)
• EPA Substance Registry System: (S)-2-Amino-3-[4-(2-azido-ethoxy)-3-nitro-benzoylamino]-propionic acid benzyl ester(215050-05-8)

Safety Data

• Hazardous Substances Data: 215050-05-8(Hazardous Substances Data)

Upstream product

• 215050-01-4 4-(2-azido-ethoxy)-3-nitro-benzoic acid 
• 215050-00-3 4-(2-azido-ethoxy)-3-nitro-benzoic acid methyl ester 
• 329-59-9 4-fluoro-3-nitro-benzoic acid methyl ester 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 13512-57-7 N-[(1,1-dimethylethoxycarbonyl)amino]-L-asparagine benzyl ester 
• 215050-02-5 3-[4-(2-azido-ethoxy)-3-nitro-benzoylamino]-2-tert-butoxycarbonylamino-propionic acid benzyl ester 

Downstream Products

• 215050-34-3 (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-(naphthalene-1-sulfonylamino)-propionic acid benzyl ester 
• 215050-07-0 (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester 
• 215050-35-4 (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-(naphthalene-1-sulfonylamino)-propionic acid 
• 215050-09-2 (S)-2-Benzenesulfonylamino-3-[4-(2-hydroxy-ethylamino)-3-nitro-benzoylamino]-propionic acid benzyl ester 
• 215050-10-5 (S)-2-Benzenesulfonylamino-3-[4-(2-hydroxy-ethylamino)-3-nitro-benzoylamino]-propionic acid 
• 215050-08-1 (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid 
• 215050-33-2 (S)-3-[4-(2-Azido-ethoxy)-3-nitro-benzoylamino]-2-(naphthalene-1-sulfonylamino)-propionic acid benzyl ester 
• 215050-06-9 (S)-3-[4-(2-Azido-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of nonpeptide integrin antagonists

Recent studies demonstrated that peptide and antibody antagonists of integrin α(v)β3 block angiogenesis and tumor growth. In this article, the design, synthesis and biological evaluation of a series of nitroaryl ether-based, nonpeptide mimetics are described. The design of these compounds was based on Merck's arylether/α-aminoacid/guanidine framework and incorporates a novel nitroaryl system. The synthesized mimetics were tested against a variety of integrins (α(v)β3, α(IIb)β3, and α(v)β5) in order to determine their binding selectivity and ability to inhibit cell adhesion. Selected compounds were also tested for their ability to inhibit angiogenesis in vivo in the CAM (chick chorioallantoic membrane) assay. From the generated compound library, compounds 16 and 19 proved to be potent and selective inhibitors of α(IIb)β3 (IC50=14nM) whereas compound 11 showed excellent in vivo inhibition of angiogenesis (at 30μg/embryo). Copyright (C) 1998 Elsevier Science Ltd.