215121-18-9Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors
Su, Ting,Yang, Hua,Volkots, Deborah,Woolfrey, John,Dam, Suiko,Wong, Paul,Sinha, Uma,Scarborough, Robert M.,Zhu, Bing-Yan
, p. 729 - 732 (2007/10/03)
The structure-activity relationship of a novel series of substituted piperazinone-based factor Xa inhibitors is described. The most potent compound 34 displays IC50 of 0.9 nM.
Selective factor Xa inhibitors
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, (2008/06/13)
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
