215164-35-5Relevant articles and documents
New piperazinyl polyazacyclophane scaffolds, libraries and biological activities
An, Haoyun,Haly, Becky D.,Cook, P. Dan
, p. 2345 - 2350 (2007/10/03)
Four novel unsymmetric piperazinyl polyazacyclophane scaffolds 1-4 were synthesized in high yields by an efficient cyclization strategy. Twenty-six libraries 12-37 (total 16000 compounds) were generated by a solution-phase combinatorial approach from 1-4 and thirty-eight functional groups. Potent antibacterial and HIV-1 tat/TAR protein-RNA disrupting activities were discovered.