215177-60-9Relevant articles and documents
Synthesis and antiviral evaluation of 5-(arylazo)salicylaldehyde thiosemicarbazone derivatives as potent anti-bovine viral diarrhea virus agents
Basyouni, Wahid M.,Abbas, Samir Y.,El-Bayouki, Khairy A. M.,Daawod, Reham M.,Elawady, Mostafa K.
, p. 2168 - 2174 (2021/06/01)
Thiosemicarbazones which previously characterized as a new class that inhibit anti-bovine viral diarrhea virus (BVDV) prompted us for synthesizing a series of new thiosemicarbazone derivatives. Thus, in this study, we reported the synthesis and antiviral evaluation of a series of 5-(arylazo)salicylaldehyde thiosemicarbazone derivatives for their expected antiviral activity. The desired products were synthesized from the condensation of 5-(arylazo)salicylaldehyde derivatives with N-(4)-substituted thiosemicarbazide derivatives. Antiviral screening was performed to test the anti-bovine viral diarrhea virus properties. From the obtained results, compounds 5, 23 and 24 showed highly selective activity against BVDV by blocking the viral RNA synthesis in cell culture. The BVDV in antiviral drug studies is valuable surrogate for the hepatitis C virus (HCV); so, the above results provided a novel candidate for the development of anti-HCV agents.
Extending the scope of amantadine drug by incorporation of phenolic azo Schiff bases as potent selective inhibitors of carbonic anhydrase II, drug-likeness and binding analysis
Channar, Pervaiz A.,Saeed, Aamer,Shahzad, Danish,Larik, Fayaz Ali,Hassan, Mubashir,Raza, Hussain,Abbas, Qamar,Seo, Sung-Yum
, p. 1692 - 1698 (2018/09/10)
A series of Amantadine-based azo Schiff base dyes 6a–6e have been synthesized and characterized by 1H NMR and 13C NMR and evaluated for their in vitro carbonic anhydrase II inhibition activity and antioxidant activity. All of the syn
Synthesis, spectral characterization, in silico and in vitro antimicrobial investigations of some Schiff base metal complexes derived from azo salicylaldehyde analogues
Sahoo, Jyotirmaya,Parween, Gulistan,Sahoo, Suprava,Mekap, Suman Kumar,Sahoo, Sabuj,Paidesetty, Sudhir Kumar
, p. 1267 - 1276 (2017/04/28)
A series of aryl / heteroarylazo substituted salicylaldehyde analogues along with the complexes of the composition [M (L)2(H2O)2].x H2O where L is deprotonated Schiff base ligand 2-[(E)-(4-methoxyphenylimino) me
DFT, characterization and investigation of vibrational spectroscopy of 4-(4-hydroxy)-3-(2-pyrazine-2-carbonyl)hydrazonomethylphenyl-diazen-yl- benzenesulfonamide and its copper(II) complex
Ammar, Reda A.A.,Alaghaz, Abdel-Nasser M.A.,Elhenawy, Ahmed A.
, p. 94 - 103 (2014/05/06)
Azo-Schiff-base complex of Cu(II) has been synthesized and characterized by elemental, spectral and thermal studies. The conductance data indicate the non-electrolytic nature of the complex. The IR spectra of the prepared complex was suggested that the az
