215177-71-2Relevant academic research and scientific papers
Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase
Augeri, David J.,O'Connor, Stephen J.,Janowick, Dave,Szczepankiewicz, Bruce,Sullivan, Gerry,Larsen, John,Kalvin, Douglas,Cohen, Jerry,Devine, Edward,Zhang, Haichao,Cherian, Sajeev,Saeed, Badr,Ng, Shi-Chung,Rosenberg, Saul
, p. 4288 - 4300 (2007/10/03)
Potent and selective non-thiol-containing inhibitors of protein farnesyltransferase are described. FTI-276 (1) was transformed into pyridyl ether analogue 19. The potency of pyridyl ether 19 was improved by modification of the biphenyl core to that of an
