215181-17-2

Basic information

• Product Name: 2H-Azirine-3-carboxylicacid,1,1-dimethylethylester(9CI)
• Synonyms: 2H-Azirine-3-carboxylicacid,1,1-dimethylethylester(9CI)
• CAS NO: 215181-17-2
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.17
• Product Categories: CARBOXYLICESTER
• Mol File: 215181-17-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Azirine-3-carboxylicacid,1,1-dimethylethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Azirine-3-carboxylicacid,1,1-dimethylethylester(9CI)(215181-17-2)
• EPA Substance Registry System: 2H-Azirine-3-carboxylicacid,1,1-dimethylethylester(9CI)(215181-17-2)

Safety Data

• Hazardous Substances Data: 215181-17-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Uses

Organic synthesis, particularly in the production of pharmaceuticals and agrochemicals

Unique structure

Includes an azirine ring and a carboxylic acid group

Application

Building block in the creation of various biologically active molecules

Safety precautions

Potential health hazards, should be handled and used with caution in a controlled laboratory setting.

Upstream product

• 215181-44-5 2,3-Diazido-propionic acid tert-butyl ester 
• 138034-79-4 tert-butyl 2,3-dibromopropionate 
• 1663-39-4 tert-Butyl acrylate 
• 215181-48-9 tert-butyl α-azidoacrylate 

Downstream Products

• 1458027-44-5 C₂₇H₄₁NO₆Si 
• 1458027-45-6 C₂₇H₄₁NO₆Si 
• 1458027-43-4 C₂₁H₂₇NO₅ 
• 1458027-42-3 C₂₁H₂₇NO₅ 

Relevant articles and documents

Catalytic Enantioselective Reaction of 2H-Azirines with Thiols Using Cinchona Alkaloid Sulfonamide Catalysts

The first catalytic enantioselective reaction of 2H-azirines with thiols has been developed. The obtained aziridines can be converted to optically active oxazolines, aziridylamides, or α-sulfonyl esters. Transformation of these optically active aziridines

Asymmetric Diels-Alder cycloadditions of d-erythrose 1,3-butadienes to achiral t-butyl 2H-azirine 3-carboxylate

Two d-erythrose 1,3-butadienes were reacted with electrophilic achiral t-butyl 2H-azirine 3-carboxylate giving cycloadducts with good yields and moderate selectivity. The isomers could be separated to give the major (R)-isomers at C-2 in approximately 50%