215306-39-1Relevant articles and documents
Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38
Henry, James R.,Dodd, John H.
, p. 8763 - 8764 (2007/10/03)
The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mohlau indole synthesis is reported.
Potent inhibitors of the MAP kinase p38
Henry, James R.,Rupert, Kenneth C.,Dodd, John H.,Turchi, Ignatius J.,Wadsworth, Scott A.,Cavender, Druie E.,Schafer, Peter H.,Siekierka, John J.
, p. 3335 - 3340 (2007/10/03)
The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
