215309-01-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Methylpiperazin-1-yl)benzoic acid is used as a pharmaceutical intermediate for the synthesis of various drugs, particularly in the development of antipsychotics and antidepressants. Its unique structure, including the piperazine ring, makes it a valuable building block in drug design, facilitating the creation of new therapeutic agents that can address unmet medical needs.
Used in Medicinal Chemistry and Drug Discovery:
In the realm of medicinal chemistry, 3-(4-Methylpiperazin-1-yl)benzoic acid serves as a key component in the research and development of novel pharmaceuticals. Its presence in the molecular structure of potential drugs allows for the exploration of its interactions with biological targets, thereby contributing to the advancement of treatments for various conditions, including mental health disorders.
3-(4-Methylpiperazin-1-yl)benzoic acid's role in the pharmaceutical industry and its application in medicinal chemistry highlight its multifaceted utility in drug development, making it an essential tool for scientists and researchers in the field.

InChI:InChI=1/C12H16N2O2/c1-13-5-7-14(8-6-13)11-4-2-3-10(9-11)12(15)16/h2-4,9H,5-8H2,1H3,(H,15,16)

Upstream product

• 849753-22-6 3-(4-methyl-piperazin-1-yl)-benzoic acid butyl ester 
• 51-75-2 nitrogen mustard 
• 474334-89-9 methyl 3-(4-methylpiperazin-1-yl)benzoate 
• 251457-29-1 3-(4-Methylpiperazinyl)-benzoic acid tert-butyl ester 
• 99-05-8 meta-aminobenzoic acid 

Downstream Products

• 1055925-78-4 N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate 
• 1055925-75-1 N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclohexyl-3-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate 
• 1055925-66-0 N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate 
• 1055925-77-3 N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yI}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide 
• 1055925-88-6 N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide 
• 1055925-74-0 N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclohexyl-3-(4-methyl-1-piperazinyl)benzohydrazide 
• 1055925-65-9 N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide 
• 1616960-87-2 N-(2-(2-methyl-1H-indol-1-yl)ethyl)-3-(4-methylpiperazin-1-yl)benzamide 
• 1422207-83-7 C₃₀H₃₈N₄O₂ 
• 1055927-86-0 3-(4-methyl-1-piperazinyl) benzoyl chloride 
• 709044-21-3 4-[3-(4-methyl-piperazin-1-yl)-benzoylamino]-benzoic acid methyl ester 

Relevant academic research and scientific papers

PURINES AS CYSTEINE PROTEASE INHIBITORS

Substituted heteroaryl nitrile derivatives of Formula I, processes for their preparation, pharmaceutical compositions comprising such compounds and use of the compounds as cysteine protease inhibitors are provided.

Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: Novel antagonists for the vascular 5-HT1B receptor

The synthesis and vascular 5-HT1B receptor activity of a novel series of substituted 3-amido phenylpiperazine and 4-(4-methyl-1-piperazinyl)-1- benzo[b]thiophene derivatives is described. Modifications to the amido linked sidechains of the 3-am

Protease inhibitors

The present invention provides bis-aminomethyl carbonyl protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.