215312-86-0

Basic information

• Product Name: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER
• Synonyms: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER;N-(E-MALEIMIDOCAPROYLOXY)-SULFOSUCCINIMIDE;N-(E-MALEIMIDOCAPROYLOXY)SULPHOSUCCINIMIDE;N-[EPSILON-MALEIMIDOCAPROYLOXY]SULFOSUCCINIMIDE ESTER;SULPHO EMCS;SULFO-EMCS;6-Maleimidocaproic acid sulfo-NHS;1-[[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]oxy]-2,5-dioxo-3-pyrrolidinesulfonic Acid SodiuM Salt
• CAS NO: 215312-86-0
• Molecular Formula: C₁₄H₁₅N₂O₉S*Na
• Molecular Weight: 0
• Product Categories: Maleimide Derivatives;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents;heteroXlink
• Mol File: 215312-86-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 158-165°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly, Sonicated)
• Stability: Moisture Sensitive
• CAS DataBase Reference: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER(215312-86-0)
• EPA Substance Registry System: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER(215312-86-0)

Safety Data

• Hazardous Substances Data: 215312-86-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 215312-86-0 differently. You can refer to the following data:
1. A water soluble sulfhydryl and amio reactive heterobifunctional crosslinking reagent. Spacer Arm: 9.4 Angstroms
2. A water soluble sulfhydryl and amio reactive heterobifunctional crosslinking reagent.Spacer Arm: 9.4 Angstroms

General Description

EMCS and its water-soluble analog Sulfo-EMCS are heterobifunctional cross-linkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these cross-linkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.