6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER, also known as Sulfo-EMCS, is a water-soluble heterobifunctional crosslinking reagent. It contains N-hydroxysuccinimide (NHS) ester and maleimide groups that enable covalent conjugation of amineand sulfhydryl-containing molecules. The compound has a spacer arm of 9.4 angstroms and is presented as a white solid.
215312-86-0
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Basic information
- Product Name: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER
- Synonyms: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER;N-(E-MALEIMIDOCAPROYLOXY)-SULFOSUCCINIMIDE;N-(E-MALEIMIDOCAPROYLOXY)SULPHOSUCCINIMIDE;N-[EPSILON-MALEIMIDOCAPROYLOXY]SULFOSUCCINIMIDE ESTER;SULPHO EMCS;SULFO-EMCS;6-Maleimidocaproic acid sulfo-NHS;1-[[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]oxy]-2,5-dioxo-3-pyrrolidinesulfonic Acid SodiuM Salt
- CAS NO:215312-86-0
- Molecular Formula: C14H15N2O9S*Na
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Maleimide Derivatives;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents;heteroXlink
- Mol File: 215312-86-0.mol
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Chemical Properties
- Melting Point: 158-165°C
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C Freezer
- Solubility: DMSO (Slightly, Sonicated)
- Stability: Moisture Sensitive
- CAS DataBase Reference: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER(CAS DataBase Reference)
- NIST Chemistry Reference: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER(215312-86-0)
- EPA Substance Registry System: 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER(215312-86-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 215312-86-0(Hazardous Substances Data)
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215312-86-0 Usage
Uses
Used in Bioconjugation:6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER is used as a heterobifunctional crosslinking reagent for covalent conjugation of amineand sulfhydryl-containing molecules. The NHS ester reacts with primary amines to form amide bonds, while the maleimide group reacts with sulfhydryl groups to form stable thioether bonds. This allows for the creation of stable bioconjugates in various applications.
Used in Research and Development:
In the field of research and development, 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER is used as a key component in the synthesis of novel bioconjugates and the study of protein-protein interactions. Its ability to form stable bonds between amine and sulfhydryl groups makes it a valuable tool for exploring the properties and functions of various biomolecules.
Used in Pharmaceutical Industry:
6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER is used as a crosslinking agent in the pharmaceutical industry for the development of drug conjugates and targeted drug delivery systems. Its ability to form stable bonds between different molecular entities allows for the creation of innovative therapeutic agents with improved efficacy and selectivity.
Used in Diagnostics:
In the diagnostics field, 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER is used as a component in the development of diagnostic tools, such as immunoassays and biosensors. Its ability to form stable bonds between amine and sulfhydryl groups enables the creation of highly specific and sensitive diagnostic agents for the detection of various biomarkers and analytes.
Overall, 6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER is a versatile and valuable compound in the fields of bioconjugation, research and development, pharmaceuticals, and diagnostics, due to its ability to form stable covalent bonds between amineand sulfhydryl-containing molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 215312-86-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,5,3,1 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.Calculate Digit Verification of CAS Registry Number 215312-86:
(8*2)+(7*1)+(6*5)+(5*3)+(4*1)+(3*2)+(2*8)+(1*6)=100
100 % 10 = 0
So 215312-86-0 is a valid CAS Registry Number.
215312-86-0Upstream product
215312-86-0Downstream Products
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6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER
