215313-00-1

Upstream product

• 15874-80-3 3-methyl-1-(phenylsulfonyl)but-2-ene 
• 556-82-1 3-methyl-2-buten-1-ol 
• 870-63-3 prenyl bromide 

Downstream Products

• 215371-71-4 2-methyl-2-(4,10-dimethyl-5-hydroxy-7-isopropenyl-8-phenylsulfonyl-13-tetrahydropyranoxy)-3E,9E-tridecadienyl-1,3-dioxolane 

Relevant academic research and scientific papers

First total synthesis of (±)-13-hydroxyneocembrene

First total synthesis of (±)-13-hydroxyneocembrene (1), starting from 6-methyl-5-hepten-2-one (6) and geraniol (7), is described. The key steps are (i) the addition of sulfur-stabilized carbanion 12 to aldehyde 9, (ii) the synthesis of 18 by using phase-transfer catalyzed coupling reaction, and (iii) low-valent titanium-induced intramolecular coupling of oxo aldehyde 3 to afford the target molecule after the final deprotection.