215365-72-3Relevant academic research and scientific papers
Nickel-catalyzed heteroannulation of o-haloanilines with alkynes
Yoshida, Yuji,Kurahashi, Takuya,Matsubara, Seijiro
, p. 1067 - 1068 (2011)
A nickel-catalyzed heteroannulation has been developed where o-haloanilines react with alkynes to afford 2,3-disubstituted indoles. IPr (1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was found to be an effective ligand for the reaction.
Synthesis of topologically constrained naphthalimide appended palladium(ii)-N-heterocyclic carbene complexes-insights into additive controlled product selectivity
Panyam, Pradeep Kumar Reddy,Sreedharan, Ramdas,Gandhi, Thirumanavelan
supporting information, p. 4357 - 4364 (2018/06/22)
Topologically constrained naphthalimide appended Pd-NHCs were synthesized and characterized. These structurally related complexes were catalytically compared with previously synthesized Pd-NHCs in the regioselective heteroannulation of o-haloanilines and
One-pot multicomponent synthesis of indoles from 2-iodobenzoic acid
Leogane, Olivier,Lebel, Helene
, p. 350 - 352 (2008/09/19)
(Chemical Equation Presented) A synergism: The multicomponent assembly of an alkyne, a nucleophile, and a carboxylic acid gave indole derivatives in good yield and high regioselectivity by a one-pot Curtius rearrangement/palladium- catalyzed indolization process (see scheme). A synergistic effect was observed; the by-product of the first reaction served as a reagent for the second step. The first synthesis of indole N-carboxamide derivatives by heteroannulation is also described.
Synthesis of 2,3-disubstituted indoles via palladium-catalyzed annulation of internal alkynes
Larock,Yum,Refvik
, p. 7652 - 7662 (2007/10/03)
The palladium-catalyzed coupling of 2-iodoaniline and the corresponding N-methyl, -acetyl, and -tosyl derivatives with a wide variety of internal alkynes provides 2,3-disubstituted indoles in good-to-excellent yields. The best results are obtained by empl
