215373-23-2

Upstream product

• 140903-48-6 phenylmethyl 3-carboxy-2(S)-(phenylmethyl)-1-propanoate 
• 131288-25-0 Benzyl (2S)-2-Benzyl-3-t-butoxycarbonyl Propionate 
• 215373-19-6 (S)-3-Benzyl-4-oxo-4-((R)-3,3,5-trimethyl-2-oxo-pyrrolidin-1-yl)-butyric acid tert-butyl ester 
• 155956-29-9 (5R)-(-)-(1'-oxo-3'-phenylpropyl)-5,3,3-trimethylpyrrolidin-2-one 
• 215373-22-1 (S)-2-Benzyl-N-tert-butoxy-succinamic acid benzyl ester 

Relevant academic research and scientific papers

First asymmetric synthesis of the Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S)-2-[2′-(N-hydroxycarbamoylmethyl)-3′- phenylpropionylamino]cyclohexane-1-carboxylic acid

The first asymmetric synthesis of Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S)-2-[2′-(N-hydroxycarbamoylmethyl)-3′- phenylpropionylamino]cyclohexane-1-carboxylic acid is achieved using lithium amide (R)-5 and pyrrolidinone auxiliary (R)-6; the pyrrolidinone auxiliary is used to create (2S)-benzylsuccinic acid derivative (S)-4 while lithium amide (R)-5 is used to synthesize tert-butyl (1S,2R)-2-aminocyclohexanecarboxylate 3.