215377-60-9

Upstream product

• 163732-94-3 meso-2,3-diveratryl-succinic acid dimethyl ester 
• 156769-15-2 meso-2,3-bis[(3,4-dimethoxyphenyl)methyl]-butane-1,4-diol 
• 215377-58-5 Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester 

Downstream Products

• 215377-61-0 (2R,3S)-4-Acetoxy-2,3-bis-(3,4-dimethoxy-benzyl)-butyric acid 

Relevant academic research and scientific papers

A chemoenzymatic synthesis of both enantiomers of a cis-lignan lactone

The stereoselective acetylation of meso-2,3-bis(3,4- dimethoxybenzyl)butanediol by vinyl acetate in the presence of Candida antarctica lipase in benzene gave the corresponding (+)-(2S,3R) monoester (ee ≥98%). Transesterification of meso-2,3-bis(3,4-dimethoxybenzyl)butyl diacetate, in the presence of the same enzyme, by ethanol in benzene/isopropyl ether gave the corresponding (-)-(2R,3S) monoester (ee ≥98%). Both enantiomers of the known cis-2,3-bis(3,4- dimethoxybenzyl)butyrolactone were synthesized from these monoesters.