215380-62-4

Upstream product

• 333747-08-3 (benzotriazol-1-yl)(5-bromo-2-hydroxyphenyl)methanone 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 52817-12-6 6-bromo-4-oxo-4H-chromene-3-carbaldehyde 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 624-31-7 4-tolyl iodide 
• 1761-61-1 5-bromosalicyclaldehyde 

Relevant academic research and scientific papers

Eco-friendly organocatalyst- And reagent-controlled selective construction of diverse and multifunctionalized 2-hydroxybenzophenone frameworks for potent UV-A/B filters by cascade benzannulation

The organocatalyst- and reagent-controlled highly selective synthesis of diversely functionalized novel 2-hydroxybenzophenone frameworks, such as 2-hydroxy-3′-formylbenzophenones, 7-(2′-hydroxybenzoyl)-2-naphthaldehydes, and 2-hydroxybenzophenones, under green conditions, for the development of potent UV-A/B filters is described. The organocatalyzed benzannulation reactions proceed individually via [3 + 3] cycloaddition for the synthesis of 2-hydroxy-3′-formylbenzophenones and [4 + 2] cycloaddition for 2-hydroxybenzophenones. With this methodology, an unprecedented double benzannulation allows one-pot construction of diverse 7-(2′-hydroxybenzoyl)-2-naphthaldehydes via [3 + 3 + 4] cycloaddition. This protocol features a broad substrate scope, high functional-group tolerance, and operational simplicity in an environmentally benign green solvent. The synthesized compounds are successfully utilized for further transformations and well characterized as potent UV-A/B filters.

First direct access to 2-hydroxybenzophenones via nickel-catalyzed cross-coupling of 2-hydroxybenzaldehydes with aryl iodides

An efficient, inexpensive and reusable NiCl2·6H2O/n-Bu4NBr catalytic system is described for the direct C-H arylation of 2-hydroxybenzaldehydes with aryl iodides for the first time.

Palladium-catalyzed direct C-H arylation of 2-hydroxybenzaldehydes with organic halides in neat water

The palladium-catalyzed cross-coupling of 2-hydroxybenzaldehydes with organic halides proceeds in the presence of n-Bu4NBr in H2O producing the corresponding 2-hydroxybenzophenones in high yields.

Synthesis of aliphatic hydroxyaryl ketones or (hetero)aryl hydroxyaryl ketones by acylation of organometallic reagents

Diverse hydroxyarenecarboxylic acids afford stable N-(hydroxyaroyl) benzotriazoles that react with heteroaryl, alkyl, and aryl Grignard or lithium reagents to give the corresponding hydroxyaryl ketones in 51-94% yields. Georg Thieme Verlag Stuttgart.

Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity

Compounds of the formula where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.