215445-56-0

Basic information

• Product Name: (4aR,7R,8aS)-8-Hydroxymethyl-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol
• CAS NO: 215445-56-0
• Molecular Weight: 311.291
• Mol File: 215445-56-0.mol

Chemical Properties

• CAS DataBase Reference: (4aR,7R,8aS)-8-Hydroxymethyl-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (4aR,7R,8aS)-8-Hydroxymethyl-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol(215445-56-0)
• EPA Substance Registry System: (4aR,7R,8aS)-8-Hydroxymethyl-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol(215445-56-0)

Safety Data

• Hazardous Substances Data: 215445-56-0(Hazardous Substances Data)

Upstream product

• 215445-55-9 (2R,3S,5R)-2-Hydroxymethyl-4-nitro-tetrahydro-pyran-3,5-diol 
• 215445-54-8 (R)-3-Hydroxy-2-(2-oxo-ethoxy)-propionaldehyde 
• 491-19-0 1,4-anhydro-D-ribitol 
• 50-00-0 formaldehyd 
• 74720-63-1 1,5-anhydro-4,6-O-benzylidene-3-deoxy-3-nitro-D-glucitol 

Downstream Products

• 203383-43-1 (4aR,7R,8S,8aS)-8-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 203383-42-0 (4aR,7R,8R,8aS)-8-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 203383-49-7 (4aR,8aS)-8-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxine 
• 203383-46-4 3-Benzoyl-1-{(4aR,7S,8S,8aS)-8-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 203383-44-2 9-{(4aR,7S,8S,8aS)-8-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-9H-purin-6-ylamine 
• 203383-47-5 1-{(4aR,7S,8S,8aS)-8-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 203383-40-8 (4aR,7R,8S,8aS)-8-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 203383-41-9 (4aR,7R,8R,8aS)-8-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-8-nitro-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 

Relevant articles and documents

Synthesis of 3'-C-branched 1',5'-anhydromannitol nucleosides as new antiherpes agents

A series of 3'-β-C-branched anhydromannitol nucleosides were conveniently synthesized starting from commercially available D-ribose. The reaction sequences were: (i) conversion of the protected pentofluranose to the corresponding nitrohexopyranose; (ii) addition of the conjugated base of the nitrosugar to formaldehyde; (iii) removal of the nitro group by n-tributyltin hydride treatment and (iv) Mitsunobu type alkylation to introduce the nucleobase. The conformation of intermediates and final compounds were deduced from NMR analysis. The thymine congener showed potent activity against herpes simplex virus (HSV).