21553-97-9

Upstream product

• 93501-29-2 2-Bromo-3,3-diphenyl-thiopropionic acid S-p-tolyl ester 
• 93501-30-5 2-Bromo-3-phenyl-3-p-tolyl-thiopropionic acid S-p-tolyl ester 
• 93501-02-1 p-thiocresyl α,β-dibromohydrocinnamate 

Relevant academic research and scientific papers

Synthesis of 3-Arylcoumarins, Thiacoumarins and Carbostyrils

3-Arylcarbostyrils (2a-f), coumarins (2g-j) and thiacoumarin (2k) have been prepared by a generalised method from α,β-dibromohydrocinnamoyl derivatives (1a-k).The intermediate dihydrocoumarins and dihydrocarbostyrils (3, Y = O, NH) have been prepared which on acid treatment furnish 2.However, treatment of 3 with a base affords the 4-arylcoumarins and carbostyrils (4).

A New Route for the Synthesis of Coumarins, Thiacoumarins and Carbostyrils

3-Arylcarbostyrils, coumarins and thiacoumarins (3) have been prepared from the respective β-aryl-α-bromodihydrocinnamoyl derivatives (2) by treatment with AlCl3.The β,β-diarylacrylic acid derivatives (4) and (9), obtained from 2, on reaction with AlCl3 afford 4-arylcarbostyrils (5) 6-methyl-4-phenylthiacoumarin (10) respectively.However the oxygen analogs (11) give 3,3-diphenyl-1-indanone (12)