215530-59-9

Basic information

• Product Name: [1,2,4]Triazolo[1,5-b]pyridazine, 6-chloro-2-(1,1-dimethylethyl)-
• Synonyms: [1,2,4]Triazolo[1,5-b]pyridazine, 6-chloro-2-(1,1-dimethylethyl)-;6-CHLORO-2-(1,1-DIMETHYLETHYL)-[1,2,4]TRIAZOLO[1,5-B]PYRIDAZINE;2-(tert-butyl)-6-chloro-[1,2,4]triazolo[1,5-b]pyridazine
• CAS NO: 215530-59-9
• Molecular Formula: C₉H₁₁ClN₄
• Molecular Weight: 210.66344
• Mol File: 215530-59-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 95-97 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.33g/cm³
• Refractive Index: 1.638
• Storage Temp.: 2-8°C
• PKA: 1.49±0.30(Predicted)
• CAS DataBase Reference: [1,2,4]Triazolo[1,5-b]pyridazine, 6-chloro-2-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2,4]Triazolo[1,5-b]pyridazine, 6-chloro-2-(1,1-dimethylethyl)-(215530-59-9)
• EPA Substance Registry System: [1,2,4]Triazolo[1,5-b]pyridazine, 6-chloro-2-(1,1-dimethylethyl)-(215530-59-9)

Safety Data

• Hazardous Substances Data: 215530-59-9(Hazardous Substances Data)

Usage

General Description

[1,2,4]Triazolo[1,5-b]pyridazine, 6-chloro-2-(1,1-dimethylethyl)- is a chemical compound with the molecular formula C10H10ClN5. It is a heterocyclic compound containing a triazolo pyridazine ring system and a chlorine atom. The presence of a tert-butyl group on the carbon atom of the pyridazine ring makes it a substituted compound. This chemical may have potential applications in the pharmaceutical industry as a building block for the synthesis of various drug molecules. It is important to handle this compound with care and follow proper safety procedures due to its potentially hazardous nature.

InChI:InChI=1/C9H11ClN4/c1-9(2,3)8-11-7-5-4-6(10)12-14(7)13-8/h4-5H,1-3H3

Upstream product

• 339528-43-7 N-(6-chloropyridazin-3-yl)-N'-hydroxy-2,2-dimethylpropanimidamide 
• 24331-71-3 N,N-dimethylpivalamide 
• 215530-60-2 N'-(6-chloropyridazin-3-yl)-N,N,2,2-tetramethylpropanimidamide 

Relevant articles and documents

Synthesis of eosinophil infiltration inhibitors with antihistaminic activity.

A series of [1, 2, 4]triazolo[1, 5-b]pyridazines (5) and imidazo[1, 2-b]pyridazines (6) having cyclic amines was synthesized and evaluated for antihistaminic activity and inhibitory effect on eosinophil infiltration. When a piperidine or a piperazine containing a benzhydryl group and a suitable spacer was incorporated at the 6-position, the fused pyridazines were found to exhibit both antihistaminic activity and an inhibitory effect on eosinophil chemotaxis. Above all, 6a showed potent antihistaminic activity, but little blockade of central H(1) receptors in contrast with its complete blockade of peripheral H(1) receptors as determined by an ex vivo binding assay. Furthermore, 6a inhibited eosinophil infiltration of the skin caused by a topical antigen challenge in sensitized guinea pigs, while an antihistamine terfenadine was not effective. After the pharmacokinetic study, 6a was found to be rapidly hydrolyzed to 6o, which was also orally active. Compound 6o, 2-[6-[[3-[4-(diphenylmethoxy)piperidino]propyl]amino]imidazo[1, 2-b]pyridazin-2-yl]-2-methylpropionic acid dihydrate (TAK-427), having both antihistaminic and antiinflammatory activity, is currently undergoing clinical trials as a therapeutic agent for atopic dermatitis and allergic rhinitis.