215584-99-9Relevant academic research and scientific papers
Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells
Park, Jin,Li, Qian,Chang, Young-Tae,Kim, Tae Sung
, p. 2589 - 2595 (2005)
Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4+ T cells, is an important stimulus for the switch of th
Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthase
Koolath, Sajeer,Monde, Kenji,Murai, Yuta,Suga, Yoshiko
supporting information, (2020/02/04)
Enantiomers or diastereomers of chiral bioactive compounds often exhibit different biological and toxicological properties. Here, we report the efficient synthesis of four stereoisomers of sphingosine and derivatization of unique chiral ceramides through a combinatorial chemistry by solid-phase activated resin ester. In addition, to test the effectivity of stereochemistry of ceramide, we demonstrated a cell-based assay of sphingomyelin synthase inhibition in the presence ofchiral unique ceramides, which suggested that libraries of this sort will be a rich source of biologically active synthetic molecules.
The synthesis and biological characterization of a ceramide library
Chang, Young-Tae,Choi, Jaehwa,Ding, Sheng,Prieschl, Eva E.,Baumruker, Thomas,Lee, Jae-Mok,Chung, Sung-Kee,Schultz, Peter G.
, p. 1856 - 1857 (2007/10/03)
A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated. Copyright
Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase
Miura, Tsuyoshi,Kajimoto, Tetsuya,Jimbo, Masayuki,Yamagishi, Kiwamu,Inokuchi, Jin-Chi,Wong, Chi-Huey
, p. 1481 - 1489 (2007/10/03)
This paper describes the new synthesis and evaluation of some morpholino- and pyrrolidinosphingolipids and mimics as inhibitors of glucosylceramide synthase. It was found that the pyrrolidino derivatives are generally more active than the morpholino derivatives and the best one was shown to be a nanomolar inhibitor. Copyright (C) 1998 Elsevier Science Ltd.
