215595-66-7Relevant articles and documents
Lysinyl macrocyclic hexaoxazoles: Synthesis and selective G-quadruplex stabilizing properties
Rzuczek, Suzanne G.,Pilch, Daniel S.,LaVoie, Edmond J.,Rice, Joseph E.
, p. 913 - 917 (2008/12/23)
Macrocyclic hexaoxazoles having one or two lysinyl side chains in which the terminal nitrogen is either a primary amine, N,N-dimethylamine, or an acetamide have been synthesized. Sodium ion has been found to be beneficial to the macrocyclization step by acting as a template around which the linear polyoxazole can organize. Each of the targeted compounds selectivity stabilizes G-quadruplex versus duplex DNA. Compounds with one valine and one lysine residue display the best combination of G-quadruplex stabilizing ability with no detectable stabilization of duplex DNA.