215597-45-8Relevant articles and documents
A novel stereoselective tin-free radical protocol for the enantioselective synthesis of pyrrolidinones and its application to the synthesis of?biologically active GABA-derivatives
Rodríguez-Soria, Verónica,Quintero, Leticia,Sartillo-Piscil, Fernando
, p. 2750 - 2754 (2008/09/19)
Optically pure 4-alkyl-pyrrolin-2-ones were synthesized from chiral N-allyl-α-bromoacetamides in high selective and stereo-controlled fashion, via a sequential 5-exo-trig radical cyclization-hydrogen or bromine atom-transfer process, under non-tin conditi
Resolution and conformational analysis of diastereoisomeric esters of cis- and trans-2-(aminomethyl)-1-carboxycyclopropanes
Duke, Rujee K.,Allan, Robin D.,Chebib, Mary,Greenwood, Jeremy R.,Johnston, Graham A. R.
, p. 2533 - 2548 (2007/10/03)
(1R,2S)-, (1S,2R)-, (1R,2R)- and (1S,2S)-2-(Aminomethyl)-1- carboxycyclopropanes, conformationally restricted analogues of the neurotransmitter γ-aminobutyric acid (GABA), have been resolved by chromatographic separation of the corresponding diastereoisomeric esters which were formed between the cis- and trans-2-(acetamidomethyl)1- carboxycyclopropanes with (R)-(-)-pantolactone. 1H NMR, semi-empirical conformational analysis, ab initio (DFT) structure and NMR shielding tensor calculations of the cis-diastereoisomers allowed the absolute configuration assignments of the cis-amino acids.
Synthesis of &γ-Aminobutyric Acid Analogue of Restricted Conformation. Part 1. The 2-(Aminomethyl)cycloalkaneacetic Acids
Kennewell, Peter D.,Matharu, Saroop S.,Taylor, John B.,Westwood, Robert,Sammes, Peter G.
, p. 2563 - 2570 (2007/10/02)
The synthesis of analogues with restricted rotatin about the C(2)-C(3) bond of γ-aminobutyric acid, namely cis- and trans-2-(aminomethyl)-cyclopropane and -cyclobutanecarboxylic acids and trans-2-(aminomethyl)cyclohexanecarboxylic acid are described.