215713-86-3Relevant academic research and scientific papers
Synthesis and conformational study of 1,2,3,4,5,6,7,8-octahydro-1,6- naphthiridines
Esipova,Borisenko,Terent'ev,Grishina,Herzshuh
, p. 742 - 747 (2006)
A new class of endocyclic enamines, 1,6-disubstituted 1,2,3,4,5,6,7,8- octahydro-1,6-naphthiridines, was synthesized from 4-piperidone imines by successive subjecting the latter to lithiation with lithium diethylamide, to alkylation with 1-bromo-3-chloropropane, and to intramolecular cyclization. All stages were carried out as a unique process without isolation of the intermediate compounds. A thorough optimization of the process conditions, workup, and product storage was carried out. The conformational study of 1,6-disubstituted 1,2,3,4,5,6,7,8-octahydro-1,6-naphthiridines was performed. Pleiades Publishing, Inc. 2006.
SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE
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Paragraph 0475, (2016/09/12)
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharma
A simple and convenient route to 1,2,3,4,5,6,7,8-octahydro-1,6- naphthyridines
Gaidarova, Elena L.,Borisenko, Anatoly A.,Chumakov, Taras I.,Mel'nikov, Andrey V.,Orlov, Ivan S.,Grishina, Galina V.
, p. 7767 - 7770 (2007/10/03)
A simple and convenient synthetic approach to the new series of 1,2,3,4,5,6,7,8-octahydro-1,6-naphthyridines 1a-j has been developed. This was achieved via a one-pot process combining metalated 4-piperidinonimine alkylation and intramolecular cyclization.
