215716-98-6Relevant academic research and scientific papers
Optically active cyclobutanone chemistry: synthesis of (-)-cyclobut-a and (±)-3′-epi-cyclobut-a
Brown, Brian,Hegedus, Louis S.
, p. 8012 - 8018 (2007/10/03)
The carbocyclic nucleoside analogues (-)-cyclobut-A and (±)-3′-epi-cyclobut-A were synthesized utilizing photolysis of the (benzyloxymethyl)(methoxy) chromium carbene complex 4 with optically active ene-carbamate 5 to produce the corresponding optically active α,α-disubstituted cyclobutanone 6. Stereoselective removal of the a-ethoxy group with inversion gave cyclobutanone 7, which was converted by existing methodology to the title compounds.
