215719-01-0Relevant academic research and scientific papers
Synthesis of 3,4-disubstituted 2,5-dihydropyrrol-1-yloxyl spin label reagents
Sar, Cecilia P.,Jekoe, Jozsef,Hideg, Kalman
, p. 1497 - 1500 (2007/10/03)
4-Alkyl(or aryl)-3-ethoxycarbonyl-2,5-dihydro-1H-pyrrol-1-yloxyl radicals 5a-g were prepared in a multistep reaction via base-catalyzed conjugate addition of 2-nitropropane to β-aryl(or -alkyl)-α, β- unsaturated-α-ethoxycarbonyl ketones to give γ-nitro ketones, followed by a cyclization to 3,4-dihydro-2H-pyrrole 1-oxides, dehydrobromination to 2H- pyrrole 1-oxides and then Grignard reaction. The esters 5a-g are versatile synthons for obtaining highly SH-specific allylic iodide 7a,c-g and methylsulfonylthiomethyl 8a-g spin label reagents.
