215721-45-2Relevant academic research and scientific papers
Synthesis of a dithio analogue of n-propyl kojibioside as a potential glucosidase I inhibitor
Andrews, John S.,Johnston, Blair D.,Pinto, B. Mario
, p. 27 - 33 (2007/10/03)
Procedures for the preparation of 3,4,6-protected 2-thio-α-D-glucopyranoside derivatives by thiolate nucleophilic displacement of the 2-O-triflate of α-D-mannopyranoside derivatives were investigated. A synthesis of n-propyl 3,4,6-tri-O-benzyl-2-thio-β-D-glucopyranoside was developed. Glycosylation of this derivative with 2,3,4,6-tetra-O-acetyl-5-thio-α-D-glucopyranosyl trichloroacetimidate gave an α/β mixture of protected n-propyl β-dithiokojibioside and β-dithiosophoroside. Deprotection of the mixture by standard methods and separation by chromatography gave n-propyl β-dithiokojibioside (1) which is a potential enzyme inhibitor of glucosidase I. Copyright (C) 1998 Elsevier Science Ltd.
