215780-33-9

Upstream product

• 70453-82-6 6-methyl-4-phenyl-1,2-dihydroquinolin-2-one 
• 215780-32-8 N¹-methoxycarbonylethyl-6-methyl-4-phenylquinolin-2(1H)-one 

Downstream Products

• 215780-39-5 2-(6-Methyl-2-oxo-4-phenyl-2H-quinolin-1-yl)-propionic acid [1-(4-chloro-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 215780-50-0 4-phenyl-1-(N¹-6'-methyl-4'-phenylquinolinopropionyl)thiosemicarbazide 
• 215780-41-9 2-(6-Methyl-2-oxo-4-phenyl-2H-quinolin-1-yl)-propionic acid [1-(2-nitro-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 215780-37-3 2-(6-Methyl-2-oxo-4-phenyl-2H-quinolin-1-yl)-propionic acid [1-(4-hydroxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 215780-40-8 2-(6-Methyl-2-oxo-4-phenyl-2H-quinolin-1-yl)-propionic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 215780-35-1 2-(6-Methyl-2-oxo-4-phenyl-2H-quinolin-1-yl)-propionic acid [1-(2,4-dichloro-phenyl)-meth-(Z)-ylidene]-hydrazide 

Relevant academic research and scientific papers

Synthesis of Some New N1-Substituted-6-methyl-4-phenyl-quinolin-2(1H)-ones

Quinolone (1) when N-alkylated with 2-chloropropionate in the presence of potassium carbonate gives 1-methoxycarbonylethyl-6-methyl-4-phenylquinolin-2(1H)-one (2) which on treatment with hydrazine hydrate yields 1-hydrazidoethyl-6-dimethyl-4-phenyl-quinolin-2(1H)-one (3). Compound 3 reacts with various aldehydes to form arylidene derivatives (4). Cycloaddition of 4 with mercaptoacetic acid gives thiazolidinones (5). Further, the reaction of 3 with phenyl isothiocyanate yields N-substituted-thiocarbamate derivative (6) which when cyclised with NaOH furnishes the mercaptotriazole (7). The reaction of 3 with 3-acetyl-6-methylpyran-2,4-dione and ethyl chloroformate gives the heteroarylalkyl products 8 and 9 respectively.