215807-97-9Relevant academic research and scientific papers
A facile transformation of the δ-hydroxy-α-amino lactones from α- furfuryl amide
Liao, Li-Xin,Zhou, Wei-Shan
, p. 12571 - 12584 (2007/10/03)
(S)- and (R)- α- furfuryl amides, obtained from the kinetic resolution of (R, S)- α- furfuryl amide using the modified Sharpless asymmetric epoxidation, have been transformed into four 8-hydroxy α- amino lactones (1S, 3S)-1, (1R, 3R)-1, (1S, 3R)-1, (1R, 3S)-1, using sharpless asymmetric dihydroxylation as the key step. The much more efficient method of the addition of chiral aldimine 10 with allylic Grignard reagent for preparation of (S, S)-1 was also achieved.
