215812-32-1Relevant academic research and scientific papers
(η5-Cyclopentadienyl)Fe(CO)2-complexes of sulfonamide anions. Acylation of the amino group in the sulfanilamide complex and its relevance to the protein labelling
Zakrzewski, Janusz,Pawlak, Maria
, p. 171 - 175 (1998)
Illumination with visible light of [CpFe(CO)2I] (Cp=η5-C5H5) with NH2SO2C6H4-p-R (R=Me, NO2, NH2) in benzene in the presence of diisopropylamine gives [CpFe(CO)2NHSO2C6H4-p-R] in 62-91% yield. The primary amino group in [CpFe(CO)2NHSO2C6H4-p-NH 2] was acylated by treatment of this complex with neat carboxylic acid anhydrides (acetic, propionic and isobutyric) or with carboxylic acid (acetic, iodoacetic, β-maleimidopropionic) and 1-[3-(dimethylamino)propyl]-3-ethyl-carbodiimide (EDC) in aqueous solutions at pH 5-6 at room temperature. The latter reaction shows that [CpFe(CO)2NHSO2C6H4-p-NH 2] can be used as an IR-detectable metallo-carbonyl reagent labelling the COOH groups in proteins and as a parent compound for a new family of reagents labelling the thiol function.
