Cas 215812-89-8,5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-2-methylsulfanyl-3,5-dihydro-imidazol-4-one

215812-89-8

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Basic information

Product Name: 5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-2-methylsulfanyl-3,5-dihydro-imidazol-4-one
Synonyms: 5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-2-methylsulfanyl-3,5-dihydro-imidazol-4-one
CAS NO:215812-89-8
Molecular Formula:
Molecular Weight: 252.724
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-2-methylsulfanyl-3,5-dihydro-imidazol-4-one(CAS DataBase Reference)
NIST Chemistry Reference: 5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-2-methylsulfanyl-3,5-dihydro-imidazol-4-one(215812-89-8)
EPA Substance Registry System: 5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-2-methylsulfanyl-3,5-dihydro-imidazol-4-one(215812-89-8)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 215812-89-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 215812-89-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,5,8,1 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 215812-89:
(8*2)+(7*1)+(6*5)+(5*8)+(4*1)+(3*2)+(2*8)+(1*9)=128
128 % 10 = 8
So 215812-89-8 is a valid CAS Registry Number.

215812-89-8Upstream product

215812-89-8Downstream Products

215812-89-8Relevant academic research and scientific papers

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity

Subtel'Na, Ivanna,Atamanyuk, Dmytro,Szymanska, Ewa,Kiec-Kononowicz, Katarzyna,Zimenkovsky, Borys,Vasylenko, Olexandr,Gzella, Andrzej,Lesyk, Roman

experimental part, p. 5090 - 5102 (2010/09/06)

Series of novel 5-arylidene-2-arylaminothiazol-4(5H)-ones and 2-aryl(benzyl)amino-1H-imidazol-4(5H)-ones were synthesized from appropriate 2-alkylthioazol-4-ones using nucleophilic substitution in position 2 by various anilines and benzylamines and Knoeve

Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin

Szymanska, Ewa,Kiec-Kononowicz, Katarzyna

, p. 355 - 362 (2007/10/03)

Various 5-(chlorobenzylidene)-2-isoniazido and 5-(chlorobenzylidene)-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated in the primary assay for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv. Eight of them exhibited >90% inhibition in the primary screening at 12.5 μg/ml. For these primarily selected compounds the actual MIC and IC50 values were determined. Two of the isoniazid derivatives, for which MIC≤3.13 μg/ml and SI>10, were selected for further screening and investigated for efficacy in vitro in a TB-infected macrophage model. The most promising compound, 5-(3-chlorobenzylidene)-2-(isonicotinoylhydrazino)-imidazoline-4-one, with activity in vitro comparable with rifampin (MIC=0.8 μg/ml, SI>78) was tested in vivo in the animal tuberculosis model but exhibited insignificant activity. For several compounds the primary screening of antimycobacterial activity against Mycobacterium avium (ATCC 25291) was conducted as well, but none of them demonstrated satisfactory activity.

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