215818-26-1

Basic information

• Product Name: 2,1,3-Benzoxadiazol-4-amine,7-fluoro-(9CI)
• Synonyms: 2,1,3-Benzoxadiazol-4-amine,7-fluoro-(9CI)
• CAS NO: 215818-26-1
• Molecular Formula: C6H4FN3O
• Molecular Weight: 153.1138632
• Product Categories: HALIDE
• Mol File: 215818-26-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,1,3-Benzoxadiazol-4-amine,7-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,1,3-Benzoxadiazol-4-amine,7-fluoro-(9CI)(215818-26-1)
• EPA Substance Registry System: 2,1,3-Benzoxadiazol-4-amine,7-fluoro-(9CI)(215818-26-1)

Safety Data

• Hazardous Substances Data: 215818-26-1(Hazardous Substances Data)

Usage

Chemical class

Benzoxadiazole derivative

Type of compound

2,1,3-Benzoxadiazol-4-amine

Fluorine atom position

7th position

Potential applications

Medicinal chemistry, drug development, scientific research

Unique properties

Presence of fluorine atom may confer unique characteristics and uses

Versatility

Has potential uses in different scientific and industrial fields

Upstream product

• 29270-56-2 4-fluoro-7-nitro-2,1,3-benzoxadiazole 
• 29270-55-1 4-fluoro-2,1,3-benzoxadiazole 

Relevant articles and documents

(AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES

Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

Effects of the substituent groups at the 4- and 7-positions on the fluorescence characteristics of benzofurazan compounds

To develop new fluorogenic reagents having the benzofurazan structure, we investigated the effects of the substituent groups at the 4- and 7-positions of the benzofurazan skeleton on the fluorescence characteristics (fluorescence intensity, maximum excitation wavelength and maximum emission wavelength). Seventy benzofurazan compounds substituted at the 4- and 7-positions were obtained for this purpose. The Hammett substituent constant (σp) was adopted as a parameter for electronic effects by substituent groups. The study using the sum and the difference of the Hammett substituent constants (σp) at the 4- and 7-positions revealed that the highly fluorescent benzofurazan compounds were classified into two groups and that singlet excitation energies, calculated by the maximum excitation and emission wavelengths, of the benzofurazan compounds were different between these two groups. The fluorescence characteristics of benzofurazan compounds substituted at the 4- and 7-positions were empirically predictable by these relationships and σp values. A new fluorogenic reagent, 4-phenylaminosulfonyl-7-fluoro-2,1,3-benzoxadiazole, for amines was developed based on this method and applied to the amino acids analysis.