21583-32-4

Basic information

• Product Name: Geraldone
• Synonyms: Geraldone
• CAS NO: 21583-32-4
• Molecular Formula: C₁₆H₁₂O₅
• Molecular Weight: 284.26348
• Mol File: 21583-32-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 534.5°Cat760mmHg
• Flash Point: 204.8°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 4.87E-12mmHg at 25°C
• Refractive Index: 1.668
• CAS DataBase Reference: Geraldone(CAS DataBase Reference)
• NIST Chemistry Reference: Geraldone(21583-32-4)
• EPA Substance Registry System: Geraldone(21583-32-4)

Safety Data

• Hazardous Substances Data: 21583-32-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H12O5/c1-20-16-6-9(2-5-12(16)18)14-8-13(19)11-4-3-10(17)7-15(11)21-14/h2-8,17-18H,1H3

Upstream product

• 56681-66-4 3-methoxy-4-acetoxybenzoyl chloride 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 34000-39-0 homobutein 

Relevant articles and documents

Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells - A SAR study

Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-κB (NF-κB) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-κB activation. The modulation of expression of two NF-κB regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-κB, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3′-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure-activity relations amongst the flavonoids as NF-κB signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-κB activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols.

Peroxidase from cell cultures of cassia didymobotrya: A review and comparison with horseradish peroxidase

The catalytic activity on flavonoids and dibenzylbutanolides and the specificity of the peroxidase isolated from 29d-old cell cultures of Cassia didymobotrya are reported. Studies on several substrates in comparison with horseradish peroxidase revealed pe