215876-81-6Relevant articles and documents
Triarylamine compound with dyhydroxyl active site and preparation method of triarylamine compound
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Paragraph 0050; 0053, (2018/09/11)
The invention relates to a preparation method of a triarylamine compound with a dyhydroxyl active site. The method includes the steps: esterification reaction; reduction reaction; hydroxyl protection;halogen amino-coupling reaction; dehydroxylation protec
Silicon-derivates for PET-Imaging
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Page/Page column 14-15, (2008/06/13)
This invention relates to silicon-derivated compounds suitable for labelling or already labelled with 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging, preferably positron emission tomography (PET).
Zinc borates: Functionalized hard nucleophiles for coupling reactions with secondary allylic acetates
Kobayashi, Yuichi,Tokoro, Yuko,Watatani, Kengo
, p. 3825 - 3834 (2007/10/03)
We have succeeded in developing zinc borates of the general structure 3 for coupling reaction with allylic acetates. The advantages of using compounds 3 are their compatibility with carbonyl groups such as aldehyde, ketone, and ester groups, and their high reactivity toward secondary allylic acetates. Zinc borates 3 were prepared from boronate esters 1 [R(T) = p-(CHO)C6H4, p-(Ac)C6H4, p-{Ac(CH2)2}C6H4, p-(Ac-OCH2)C6H4, p-{AcO(CH2)3}C6H4, p-{EtO2C(CH2}2}C6H4, (E)-CH=CH(CH2)4OAc] with MeZnCl; subsequent treatment with allylic acetates 4 [R = n-C5H11, c-C6H11, (CH2)2CH(-O(CH2}2O-)] in the presence of NiCl2(PPh3)2 (10 mol-%) in THF-DMI (1,3-dimethyl-2-imidazolidinone) (10 equiv.) at 40-50 °C overnight furnished the coupling products 5 in good yields. Among the products, 5bb, possessing one free and one protected aldehyde group, is a highlight of this type of reaction. The stereochemical aspects of the reaction were also examined. Thus, the alkenyl groups of (E)- and (Z)-alkenyl borates 3b and c were transformed with retention of the olefinic geometry into acetates 4a and b (R = n-C5H11, c-C6H11), while reaction of cyclic acetate 11 proceeded with inversion at the carbon center involved in the reaction. In addition, we found that the anions generated from (EtO)2P(= O)CH2CO2Et and (MeO)2P(=O)CH2Ac under Masamune's conditions attacked the aldehyde carbon in the boronate 1d to produce - after reduction of the double bond - the boronate esters 1i and 1j, respectively, in good yields.