215876-81-6

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 25574-11-2 3-(4-bromophenyl)propanol 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 75567-84-9 methyl 3-(4-bromopehynl)propanoate 
• 326496-52-0 tert-butyl 3-(4-bromophenyl)propanoate 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 1105506-49-7 4-(3-{tetrahydropyran-2-yloxy}propyl)-4',4''-dimethoxytritanol 
• 850568-48-8 [4-(3-hydroxypropyl)phenyl]boronic acid 
• 215876-86-1 2-[4-(3-acetoxypropyl)phenyl]-4,5-dimethyl-1,3,2-dioxaborolane 

Relevant academic research and scientific papers

Triarylamine compound with dyhydroxyl active site and preparation method of triarylamine compound

The invention relates to a preparation method of a triarylamine compound with a dyhydroxyl active site. The method includes the steps: esterification reaction; reduction reaction; hydroxyl protection;halogen amino-coupling reaction; dehydroxylation protec

Organofluorosilanes as model compounds for18F-labeled silicon-based PET tracers and their hydrolytic stability: Experimental data and theoretical calculations (PET = Positron Emission Tomography)

Silicon chemistry has only recently been discovered by radiochemists as a straightforward tool for the introduction of 18F into biomolecules for positron emission tomography (PET) imaging. 18F-labeled PET tracers must be stable towar

Silicon-derivates for PET-Imaging

This invention relates to silicon-derivated compounds suitable for labelling or already labelled with 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging, preferably positron emission tomography (PET).

Silicon derivatives for PET imaging

This invention relates to silicon-derivated compounds suitable for labelling or already labelled with 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of

Zinc borates: Functionalized hard nucleophiles for coupling reactions with secondary allylic acetates

We have succeeded in developing zinc borates of the general structure 3 for coupling reaction with allylic acetates. The advantages of using compounds 3 are their compatibility with carbonyl groups such as aldehyde, ketone, and ester groups, and their high reactivity toward secondary allylic acetates. Zinc borates 3 were prepared from boronate esters 1 [R(T) = p-(CHO)C6H4, p-(Ac)C6H4, p-{Ac(CH2)2}C6H4, p-(Ac-OCH2)C6H4, p-{AcO(CH2)3}C6H4, p-{EtO2C(CH2}2}C6H4, (E)-CH=CH(CH2)4OAc] with MeZnCl; subsequent treatment with allylic acetates 4 [R = n-C5H11, c-C6H11, (CH2)2CH(-O(CH2}2O-)] in the presence of NiCl2(PPh3)2 (10 mol-%) in THF-DMI (1,3-dimethyl-2-imidazolidinone) (10 equiv.) at 40-50 °C overnight furnished the coupling products 5 in good yields. Among the products, 5bb, possessing one free and one protected aldehyde group, is a highlight of this type of reaction. The stereochemical aspects of the reaction were also examined. Thus, the alkenyl groups of (E)- and (Z)-alkenyl borates 3b and c were transformed with retention of the olefinic geometry into acetates 4a and b (R = n-C5H11, c-C6H11), while reaction of cyclic acetate 11 proceeded with inversion at the carbon center involved in the reaction. In addition, we found that the anions generated from (EtO)2P(= O)CH2CO2Et and (MeO)2P(=O)CH2Ac under Masamune's conditions attacked the aldehyde carbon in the boronate 1d to produce - after reduction of the double bond - the boronate esters 1i and 1j, respectively, in good yields.